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The department are involved in a new EPSRC/SFI funded project, TORC: Supercoiling-driven gene control in synthetic DNA circuits

Posted on 10 June 2021

This is a three year joint project between Leeds Physics (Sarah Harris, PI), York CS (Susan Stepney), and Trinity College Dublin Microbiology (Carsten Kroeger and Charles Dorman)

At York, we are designing and evaluating novel computational models and languages so that synthetic biological systems can be designed to exploit DNA supercoiling, a process that controls gene expression.

TCD are providing wetlab experimental data, and Leeds are performing detailed simulations of the observed supercoiling processes.

We are delighted to be part of this highly cross-disciplinary project, and look forward to doing much exciting and valuable science over the next 3 years.