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Protein Structure Matching
As part of an INTAS project(04-77-7178) we have been looking at the problem of protein structure matching. Proteins consist of sequences of aminoacids ('sites') which form into complex three-dimensional structures. Both the chemical properties of the sites and the 3D structure are crucial to the function of the protein in biological systems. Proteins can have very different sequences but perform similar functions by virtue of their shape. The goal of this work is to take a graph-matching approach to the problem of comparing these structures. The proteins are represented by graphs and are matching using geometric and relational information from the graph representation. Ultimately, we hope to outperform systems such as DALI and MATRAS in identifying protein similarity. Contact:Richard Wilson   
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